{"id":771,"date":"2026-03-30T15:05:35","date_gmt":"2026-03-30T07:05:35","guid":{"rendered":"https:\/\/zh.hengkangpharm.cn\/?p=771"},"modified":"2026-03-30T15:13:33","modified_gmt":"2026-03-30T07:13:33","slug":"%e5%9c%a8%e7%ba%bf%e7%ba%a2%e5%a4%96%e6%8a%80%e6%9c%af%e7%a0%b4%e8%a7%a3%e5%af%a1%e6%a0%b8%e8%8b%b7%e9%85%b8%e6%b0%a8%e8%a7%a3%e8%bf%87%e7%a8%8b%e7%9b%91%e6%b5%8b%e9%9a%be%e9%a2%98","status":"publish","type":"post","link":"https:\/\/www.hengkangpharm.cn\/index.php\/2026\/03\/30\/%e5%9c%a8%e7%ba%bf%e7%ba%a2%e5%a4%96%e6%8a%80%e6%9c%af%e7%a0%b4%e8%a7%a3%e5%af%a1%e6%a0%b8%e8%8b%b7%e9%85%b8%e6%b0%a8%e8%a7%a3%e8%bf%87%e7%a8%8b%e7%9b%91%e6%b5%8b%e9%9a%be%e9%a2%98\/","title":{"rendered":"\u5b9e\u65f6\u6d1e\u5bdf\uff1a\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/zh.hengkangpharm.cn\/wp-content\/uploads\/2026\/03\/\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898-1024x683.png\" alt=\"\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898\" class=\"wp-image-773\" srcset=\"https:\/\/www.hengkangpharm.cn\/wp-content\/uploads\/2026\/03\/\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898-1024x683.png 1024w, https:\/\/www.hengkangpharm.cn\/wp-content\/uploads\/2026\/03\/\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898-300x200.png 300w, https:\/\/www.hengkangpharm.cn\/wp-content\/uploads\/2026\/03\/\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898-768x512.png 768w, https:\/\/www.hengkangpharm.cn\/wp-content\/uploads\/2026\/03\/\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898-1536x1024.png 1536w, https:\/\/www.hengkangpharm.cn\/wp-content\/uploads\/2026\/03\/\u5728\u7ebf\u7ea2\u5916\u6280\u672f\u7834\u89e3\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\u76d1\u6d4b\u96be\u9898-2048x1365.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5be1\u6838\u82f7\u9178\u836f\u7269\u51ed\u501f\u5176\u9ad8\u7279\u5f02\u6027\u548c\u5e7f\u6cdb\u7684\u9776\u70b9\u8986\u76d6\uff0c\u6b63\u5728\u4e3a\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u6162\u6027\u75be\u75c5\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u5e0c\u671b\u3002\u7136\u800c\uff0c\u8fd9\u7c7b\u836f\u7269\u7684\u751f\u4ea7\u5de5\u827a\u4e2d\uff0c\u6709\u4e00\u4e2a\u5173\u952e\u73af\u8282\u957f\u671f\u56f0\u6270\u7740\u5236\u836f\u4f01\u4e1a\u2014\u2014<strong>\u6c28\u89e3\u53cd\u5e94<\/strong>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6c28\u89e3\u662f\u5be1\u6838\u82f7\u9178\u5408\u6210\u540e\u4ece\u56fa\u76f8\u8f7d\u4f53\u4e0a\u5207\u5272\u4e0b\u6765\u3001\u5e76\u8131\u9664\u78b1\u57fa\u4fdd\u62a4\u57fa\u7684\u6838\u5fc3\u6b65\u9aa4\u3002\u4f20\u7edf\u5de5\u827a\u4e2d\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u51e0\u4e4e\u5b8c\u5168\u4f9d\u8d56<strong>\u79bb\u7ebf\u53d6\u6837\u68c0\u6d4b<\/strong>\uff1a\u64cd\u4f5c\u4eba\u5458\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u4ece\u53cd\u5e94\u4f53\u7cfb\u4e2d\u53d6\u6837\uff0c\u7a00\u91ca\u540e\u7528\u7d2b\u5916\u5206\u5149\u5149\u5ea6\u8ba1\u6d4b\u5b9a\u6d53\u5ea6\u3002\u8fd9\u79cd\u505a\u6cd5\u4e0d\u4ec5\u64cd\u4f5c\u7e41\u7410\u3001\u6613\u5f15\u5165\u53d6\u6837\u8bef\u5dee\uff0c\u66f4\u5173\u952e\u7684\u662f\u5b58\u5728<strong>\u76d1\u6d4b\u5ef6\u8fdf<\/strong>\u2014\u2014\u5f53\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u53cd\u5e94\u5b8c\u6210\u65f6\uff0c\u5f80\u5f80\u5df2\u8fc7\u53cd\u5e94\u7ec8\u70b9\u6570\u5341\u5206\u949f\u751a\u81f3\u6570\u5c0f\u65f6\uff0c\u5bfc\u81f4\u6279\u95f4\u5dee\u5f02\u5927\u3001\u4ea7\u7269\u964d\u89e3\u98ce\u9669\u9ad8\u3001\u751f\u4ea7\u96be\u4ee5\u8fde\u7eed\u5316\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u65e5\uff0c\u6c88\u9633\u836f\u79d1\u5927\u5b66\u4e0e\u77f3\u836f\u96c6\u56e2\u8054\u5408\u53d1\u8868\u4e8e\u300aOrganic Process Research &amp; Development\u300b\u7684\u7814\u7a76\u300aReal-Time Process Monitoring Ammonolysis of Oligonucleotides with Online FTIR Spectroscopy\u300b\uff0c\u9996\u6b21\u5c06<strong>\u5728\u7ebf\u8870\u51cf\u5168\u53cd\u5c04-\u5085\u91cc\u53f6\u53d8\u6362\u7ea2\u5916\u5149\u8c31\uff08ATR-FTIR\uff09<\/strong>\u6280\u672f\u5f15\u5165\u5be1\u6838\u82f7\u9178\u6c28\u89e3\u8fc7\u7a0b\uff0c\u5b9e\u73b0\u4e86\u8fd9\u4e00\u5173\u952e\u6b65\u9aa4\u7684\u5b9e\u65f6\u3001\u65e0\u635f\u3001\u7cbe\u51c6\u76d1\u6d4b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e3a\u4f55\u662f\u7ea2\u5916\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f20\u7edf\u7d2b\u5916\uff08UV\uff09\u68c0\u6d4b\u5728260 nm\u5904\u53ef\u5b9a\u91cf\u6838\u9178\uff0c\u4f46\u5176\u7ebf\u6027\u8303\u56f4\u4ec5\u9002\u7528\u4e8e0\u201310 mg\/mL\u7684\u7a00\u6eb6\u6db2\u3002\u800c\u5de5\u4e1a\u6c28\u89e3\u6db2\u4e2d\uff0c\u5be1\u6838\u82f7\u9178\u6d53\u5ea6\u53ef\u8fbe50\u201380 mg\/mL\uff0c\u8fdc\u8d85UV\u7684\u68c0\u6d4b\u4e0a\u9650\u3002\u6c34\u5bf9\u7ea2\u5916\u6709\u5f3a\u5438\u6536\uff0c\u4f46ATR\u63a2\u9488\u901a\u8fc7\u77ed\u5149\u7a0b\u8bbe\u8ba1\uff08\u7ea60.5\u20132 \u03bcm\uff09\uff0c\u6210\u529f\u201c\u538b\u5236\u201d\u4e86\u6c34\u7684\u5e72\u6270\uff0c\u4f7f\u6eb6\u8d28\u7684\u7ea2\u5916\u4fe1\u53f7\u6e05\u6670\u53ef\u8fa8\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u56e2\u961f\u9996\u5148\u5bf9\u5be1\u6838\u82f7\u9178\u6807\u51c6\u54c1\u8fdb\u884c\u4e86\u7ea2\u5916\u7279\u5f81\u5cf0\u6307\u8ba4\uff0c\u786e\u5b9a\u4e86\u56db\u4e2a\u5173\u952e\u6ce2\u6570\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>1232 cm\u207b\u00b9<\/strong>\uff1a\u78f7\u9178\u4e8c\u916f\u952eO=P-O\u4e0d\u5bf9\u79f0\u4f38\u7f29\u632f\u52a8<\/li>\n\n\n\n<li><strong>1457 cm\u207b\u00b9<\/strong>\uff1a\u78b1\u57fa\u6c28\u57fa-NH\u2082\u9762\u5185\u5f2f\u66f2\u632f\u52a8<\/li>\n\n\n\n<li><strong>1504 cm\u207b\u00b9<\/strong>\uff1a\u9170\u80fa\u57fa-C(O)-NH-\u9762\u5185\u5f2f\u66f2\u632f\u52a8<\/li>\n\n\n\n<li><strong>1635 cm\u207b\u00b9<\/strong>\uff1aC=C\u548cC=N\u4f38\u7f29\u632f\u52a8<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u57280\u2013200 mg\/mL\u6d53\u5ea6\u8303\u56f4\u5185\uff0c\u8fd9\u56db\u4e2a\u7279\u5f81\u5cf0\u7684\u5cf0\u9ad8\u4e0e\u6d53\u5ea6\u5448\u73b0<strong>\u826f\u597d\u7684\u7ebf\u6027\u5173\u7cfb<\/strong>\uff08R\u00b2\u5747\u5927\u4e8e0.97\uff09\uff0c\u4e3a\u5728\u7ebf\u5b9a\u91cf\u5960\u5b9a\u4e86\u575a\u5b9e\u57fa\u7840\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u7a33\u5065\u8868\u73b0<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u9a8c\u8bc1\u8be5\u65b9\u6cd5\u7684\u666e\u9002\u6027\uff0c\u7814\u7a76\u56e2\u961f\u8bbe\u8ba1\u4e86\u591a\u79cd\u5de5\u827a\u6761\u4ef6\u7ec4\u5408\uff1a\u4e0d\u540c\u6c28\u89e3\u6e29\u5ea6\uff0836\u00b0C vs 25\u00b0C\uff09\u3001\u4e0d\u540c\u56fa\u76f8\u8f7d\u4f53\u8f7d\u91cf\uff08250 \u03bcmol\/g vs 350 \u03bcmol\/g\uff09\u3001\u4e0d\u540c\u8f7d\u4f53\u7c7b\u578b\uff08\u805a\u82ef\u4e59\u70efPS vs \u53ef\u63a7\u5b54\u73bb\u7483CPG\uff09\u3001\u4ee5\u53ca\u4e0d\u540c\u6c28\u6c34\u6295\u6599\u6bd4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6e29\u5ea6\u8d8a\u9ad8\uff0c\u6c28\u89e3\u5207\u5272\u6548\u7387\u8d8a\u9ad8\uff0836\u00b0C\u6bd425\u00b0C\u5feb\u7ea665\u5206\u949f\uff09<\/li>\n\n\n\n<li>\u8f7d\u4f53\u8f7d\u91cf\u8d8a\u9ad8\uff0c\u5207\u5272\u6548\u7387\u8d8a\u4f4e<\/li>\n\n\n\n<li>\u6c28\u6c34\u6295\u6599\u6bd4\u5f71\u54cd\u4e0d\u663e\u8457<\/li>\n\n\n\n<li>CPG\u8f7d\u4f53\u7684\u5207\u5272\u6548\u7387<strong>\u8fdc\u9ad8\u4e8ePS\u8f7d\u4f53<\/strong>\uff08\u4ec5\u970028\u5206\u949f\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c06\u5728\u7ebf\u7ea2\u5916\u6d4b\u5f97\u7684\u5cf0\u9ad8-\u65f6\u95f4\u66f2\u7ebf\u4e0e\u79bb\u7ebfUV\u6d4b\u5f97\u7684\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u8fdb\u884c\u76f8\u5173\u6027\u5206\u6790\uff0c<strong>\u56db\u4e2a\u7279\u5f81\u5cf0\u7684Pearson\u76f8\u5173\u7cfb\u6570\u5747\u5927\u4e8e0.9<\/strong>\uff0c\u5176\u4e2d1232 cm\u207b\u00b9\u78f7\u9178\u9aa8\u67b6\u5cf0\u76f8\u5173\u6027\u6700\u4f18\uff0c\u5728\u4e94\u79cd\u5b9e\u9a8c\u6761\u4ef6\u4e0b\u5747\u63a5\u8fd10.99\u3002\u8fd9\u8bf4\u660e\u5728\u7ebf\u7ea2\u5916\u7cfb\u7edf\u5728\u4e0d\u540c\u5de5\u827a\u6761\u4ef6\u4e0b\u5747\u80fd\u7a33\u5b9a\u3001\u51c6\u786e\u5730\u53cd\u6620\u6c28\u89e3\u8fdb\u7a0b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4ece\u5b9e\u9a8c\u5ba4\u5230\u5de5\u4e1a\u89c4\u6a21<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u56e2\u961f\u8fdb\u4e00\u6b65\u6a21\u62df\u5de5\u4e1a\u751f\u4ea7\u7ebf\uff0c\u642d\u5efa\u4e86\u4e00\u5957\u5305\u542b\u6c28\u89e3\u7f50\u3001\u5faa\u73af\u6cf5\u3001\u7ea2\u5916\u63a2\u6d4b\u5668\u548c\u53cd\u5e94\u67f1\u7684\u5728\u7ebf\u6c28\u89e3\u7cfb\u7edf\u3002\u5728\u88c5\u8f7d\u4e861895 \u03bcmol\u5408\u6210\u89c4\u6a21\u7684Unylinker PS 250\u8f7d\u4f53\u540e\uff0c\u76f4\u63a5\u5bf9\u5408\u6210\u67f1\u5185\u7684\u5be1\u6838\u82f7\u9178\u8fdb\u884c\u5728\u7ebf\u6c28\u89e3\u76d1\u6d4b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ed3\u679c\u4ee4\u4eba\u632f\u594b\uff1a\u6c28\u89e3\u5207\u5272\u7ec8\u70b9\u4e3a165\u5206\u949f\uff0c\u4e0e\u5b9e\u9a8c\u5ba4\u5c0f\u8bd5\uff08155\u5206\u949f\uff09\u9ad8\u5ea6\u543b\u5408\uff0c\u4e24\u8005\u76f8\u5173\u7cfb\u6570\u9ad8\u8fbe<strong>0.9968<\/strong>\u3002\u56db\u4e2a\u7ea2\u5916\u7279\u5f81\u5cf0\u4e0eUV\u66f2\u7ebf\u7684\u76f8\u5173\u6027\u518d\u6b21\u5168\u90e8\u5927\u4e8e0.9\u3002\u8fd9\u610f\u5473\u7740\uff0c\u8be5\u7cfb\u7edf\u5728\u4e0d\u540c\u89c4\u6a21\u3001\u4e0d\u540c\u6761\u4ef6\u4e0b\u5747\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u7a33\u5b9a\u6027\u548c\u901a\u7528\u6027\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7a81\u7834\u6027\u610f\u4e49<\/h2>\n\n\n\n<p 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